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KMID : 1145520190050020113
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Journal of Radiopharmaceuticals and Molecular Probes
2019 Volume.5 No. 2 p.113 ~ p.119
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Enhanced macrophage uptake of radiolabeled liposome triggered by ginseng extracts
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Lee Woong-Hee
Rhee Man-Hee
Yoo Jeong-Soo
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Abstract
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During tumor progression various immunosuppressive cells are recruited to a tumor microenvironment(TME). Tumor-associated macrophages (TAMs) are particularly abundant in TME. Based on their function,macrophages are categorized into two phenotypes: tumoricidal M1 and tumor-supportive M2. Generally, TAMsclosely resemble M2-macrophages and lead to tumor growth. However, their phenotype can be changed byimmune activator from M2 to M1 and thus promote tumor immunotherapy. Ginseng extracts are well knownfor its anti-tumor and anti-inflammatory effects from numerous reported studies. However, the mechanismof their effects is still not clear. Recently, some studies suggested that ginseng extracts induced immuneactivation as well as anti-tumor activities by a repolarization of activated macrophage from M2 phenotype to M1phenotype. But, further verification about the mechanism as to how ginseng extracts can stimulate the immuneresponse is still needed. In this study, we investigated whether ginseng extracts can alter the phenotype fromM2 macrophages to M1 macrophages in mice by using a radiolabeled liposome. And we also evaluated thepotential of radiolabeled liposome as a nuclear imaging agent to monitor the transition of phenotype of TAMs.
In conclusion, the ginseng extracts seem to change the phenotype of macrophages from M2 to M1 like aslipopolysaccharide (LPS) in mice.
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KEYWORD
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Ginseng extracts, Tumor-associated macrophages, M1 phenotype, Liposome
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